Can't help but counter this claim by stating that buying drugs via Silk Road is probably not very destructive in any sane analysis, especially compared to street level drug dealing.
There's no corners to hold, no rivals to fight with territory over, no deals to go bad, no real access by minors, and no real impedance to the function of any tangible physical location or bystander.
Seriously. The way he invokes the words "our social fabric" makes it out like Forrest was personally affected. It's easy to imagine Urlbricht rehabilitating and becoming a productive member of society but instead his life has just been destroyed. It's not justice and it's not the right thing to do.
If one person decides to put another person in a cage for the rest of their life, it's clearly a horrendous stomach turning crime. It's no less horrendous when the justice system does it. But we've decided that it's a necessary evil that society requires. We should be working as a society to minimize the necessary evil and rehabilitate people but we're not and it's a tragedy.