What does this construction imply about BB(n)? In what sense is the BB sequence even well-defined if we can prove that it can't be determined?
(Edited for clarity.)
Every BB number can be determined. However, each one must require zillions of special cases which require their own reasoning---this is the only way to prevent the BB numbers from being computable.
So, if you consider, for example, the proof of the four-color theorem (which amounts to checking many special cases), as mathematics, then mathematics surely can determine BB(n). It's just extremely hard---as hard as doing all of mathematics (in the sense that if you could easily get BB(n) you could then take a logical proposition you are interested in proving in some axiomatic system and construct a TM to derive the statement using those axioms. Then, count how many states that TM has, and start running it. If it runs for more than BB(# states), there is no proof from your system of your proposition).