zlacker

>>bookof+(OP)
I was going to say, "finally something that ivermectin can help with!" except https://pubmed.ncbi.nlm.nih.gov/7974686/

>>MPSimm+h8
Ivermectin is a very good dewormer! Most 2020 crap studies were easy to make because ivermectin was already distributed to big populations as a dewormer.

I'm the guy that every time someone calls it a good horse dewormer I reply: "And a good human dewormer too!"

>>gus_ma+lq
> Ivermectin is a very good dewormer!

And that may be responsible for some false positives in ivermectin studies for COVID - if a patient has a parasitic infection as well as COVID, treating the parasites will improve their outcome.

>>duskwu+ga2
Wasn't the ivermectin hypothesis based on it blocking NS3 helicase preventing double-stranded viral RNA from being unwound after replication? Paxlovid targets a few steps earlier by blocking 3CL protease that chops viral RNA into functional parts of a virus.

>>storus+ed2
That may have been the theory, but it seems more likely that, inasmuch as it appeared to improve outcomes in some trials, it did so by treating parasitic infections which were concurrently present. (Which makes sense! That's its primary application, after all.)