zlacker

>>giulio+(OP)
>The share of U.S. households reporting at least one user rose from about 11% in late 2023 to more than 16% by mid-2024.

I was wondering how you could get such a high impact overall. But it seems one in 6 households are on GLP-1 drugs in the US.

In my friend circle in Germany I don't even know one single person on this stuff.

It's insane to me that so many people need these to get off the processed foods killing them in the US.

>>carlmr+B5
I started a GLP-1 in October. I've been eating healthy and exercising for a decade, but I was still in the obese category and blood sugar tests indicated I was at the edge of pre-diabetes. If I pushed hard on calorie reduction or exercise, I could gain 10-20% improvement, but it seemed like that would always reverse itself when I'd hit an injury or got sick. I'm hitting my mid-40s and decided it was time for a drastic change. I could have continued yo-yo dieting or opt for a solution that gets me to a healthy BMI within a year.

I gained a lot of weight during puberty, coupled with a less healthy diet in my youth. I suspect many folks are in the same boat - by the time they realize they need to eat/exercise, it's too late. Their metabolic system has been compromised by either diet, hormones, genetics, whatever.

In four months on a GLP-1, I've dropped about 18kg and since I coupled resistance training, I've increased on various strength parameters. The sudden reduction in weight has benefited my activity level substantially. There tends to be two classes of folks - those who need to stay on this drug forever and those who don't - I'm hoping in the end I fall into the don't, but I'm going to let the data from my continuous glucose monitor decide that.

I highly recommend the book "Ozempic Revolution" if you're considering the pros/cons of this path.

>>sgwizd+TV
Wdym you were eating healthy for a decade and still obese? How does that work. A diet where you eat to obesity isn't healthy.

And how did surpressing your hunger via GLP-1 drugs (a pure change to a more healthy diet for you) lead to big changes, if you apparently already had such a healthy diet.

Seems to me your diet was unhealthy for a decade and now isn't.

>>NoLink+aG2
Think of it this way - once you're in a state of obesity, resolving that situation is quite difficult. Eating healthy may not be enough, particularly if there are other metabolic issues going on.

The imbalance of fat to muscle leads to insulin resistance. Insulin resistance gets in the way of weight loss. After a long time of trying other means, I decided to directly tackle the insulin resistance problem. And it's been the only thing that's worked.

>>sgwizd+1t3
Agreed, but thermodynamics (calorie in/out) still holds. If you actually eat healthy (say 2500 calories), you will lose weight if you're obese and need >3000 to maintain weight, period.

Sustaining that healthy diet is harder insulin resistance, agreed!

But you said you ate healthy for a decade. To me that's not eating obesity-maintenance level amounts of otherwise healthy foods, but rather eating healthy foods at a normal (say 2500 kcal daily) amount.

In other words, under your statement the behavioral impact of insulin resistance was already overcome, you were eating properly, and still didn't lose weight. And that's just not conform the science, which states that you lose weight even with high insulin resistance, as long as you're eating healthy (i.e. in a caloric deficit vis-a-vis obesity level maintenance).