zlacker

>>giulio+(OP)
> “The data show clear changes in food spending following adoption,” Hristakeva said. “After discontinuation, the effects become smaller and harder to distinguish from pre-adoption spending patterns.”

It's interesting that overall spending doesn't decrease that much in the end, although shifting from snacks to fruit is the kind of change health advocates have always wanted?

>>nemoma+j4
After discontinuation of Ozempic, people start to gain the weight again (and buy again more food), that’s why the spending changes again.

>>giulio+R5
Which is no surprise to anybody with common sense, the data for discontinuing GLP-1s show exactly the intuitive outcome. Zero diet change, zero habit change for the vast majority of users. Weight loss is accomplished via biochemical tricks to eat less volume of calorie dense junk food, rather than diet substitution. When the artificial appetite suppression ends, volume of the same food increases again leading to weight yo-yo. Plus why start to exercise when you’ve got a magic weight loss drug?

Don’t get me wrong, there are some people using these drugs to get out of a pit of inertia with weight and sedentary lifestyles. But it’s small. GLP-1 drugs will have most users hooked for life because they don’t have the discipline and motivation to maintain the weight loss without it. Cha-Ching!

>>jacobt+Uv
> they don’t have the discipline and motivation to maintain the weight loss

That argument has been tried for years and yet it fails nearly 100% of the time. Should we be trying something different than claiming it's a moral issue? Or is that too scientific?

>>rootus+hQ
Why do we need to try anything? This comes down to individualism versus collectivism.

Besides, the logical consequence of the portion of my comment you highlighted is that the majority of GLP-1 patients will need to be on these drugs forever to maintain these benefits long-term. We have precisely one trial of 5+ years of patients taking liraglutide, and ~2 years for semaglutide. Some side effects and long-term consequences could be entirely unknown.

>>jacobt+n71
All the side effects I've seen of GLP-1s are positive, and we've had diabetes patients taking them for much longer than that.

Anyway, it's fairly obvious that discipline is not a solution to weight loss, because weight gains a) happened in lab and pet animals on the same timescales they happened to humans and b) are reversed by moving to higher altitudes.

So to be productive, you should be telling people to move to Colorado.