zlacker

[return to "Adenosine on the common path of rapid antidepressant action: The coffee paradox"]
1. MilkyW+Jl[view] [source] 2025-12-06 00:50:28
>>PaulHo+(OP)
"The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism"

More evidence for Chris Palmer's 'Metabolic Theory of Mental Disorders'

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2. Murome+so[view] [source] 2025-12-06 01:18:19
>>MilkyW+Jl
It kinda makes sense if you consider depression to be a mechanism to get into winter hibernation. It's just we can't hibernate and even if we could, somebody has to pay them bills.
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3. port11+6t1[view] [source] 2025-12-06 14:42:30
>>Murome+so
But are we built for hibernation? Or is the capacity for depression just a biological mistake for us?
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4. Murome+zj2[view] [source] 2025-12-06 22:01:15
>>port11+6t1
We are not build for anything. It's a legacy codebase. Some stuff stopped working, but nobody removed the surrounding utility codes and the config entry to enable it.
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5. port11+z03[view] [source] 2025-12-07 06:29:03
>>Murome+zj2
Damned legacy code and technical debt always ruining everything.
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