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[return to "Adenosine on the common path of rapid antidepressant action: The coffee paradox"]
1. k1musa+Vi[view] [source] 2025-12-06 00:26:03
>>PaulHo+(OP)
On chronic coffee consumption: "One meta-analysis found that RR coffee 0.757, RR caffeine 0.721 (12). Another one found RR 0.76, with an optimal protective effect at ∼400 mL/day (13). In comparison to many drug treatments that have an effect size in this range, this is not a small effect size. A risk reduction of 20 to 25% is quite impressive."

As if I needed another reason to drink coffee.

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2. boothb+Wj[view] [source] 2025-12-06 00:33:25
>>k1musa+Vi
One thing I've learned over the years is that specifically setting out to enjoy and appreciate something on a daily basis is beneficial to overall satisfaction with life. And for me, that's my morning cuppa before the rest of the house wakes up. Is it (just) the coffee or is it (also) the rituals surrounding coffee?
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3. reacto+al[view] [source] 2025-12-06 00:44:08
>>boothb+Wj
It’s 100% the addiction.

It’s ok, me too. At home I’m a 4-6 cup a day drinker. On the go 2-3 Starbucks. I have a serious problem.

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4. superk+Jy[view] [source] 2025-12-06 03:02:52
>>reacto+al
Caffeine is not chemically addictive. It can lead to depedency but that is not addiction. Motivation and wanting are not altered but unpleasant withdrawl effects can occur.
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5. ses198+qE[view] [source] 2025-12-06 04:03:16
>>superk+Jy
What’s the point of this distinction, what does it mean that it’s not chemically addictive? It causes withdrawals, dependence, it definitely acts on brain chemistry.
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6. hirvi7+N22[view] [source] 2025-12-06 19:25:21
>>ses198+qE
A lot of substances cause withdrawals/dependence and act of brain chemistry, e.g., the vast array of psychiatric drugs. However, I have never seen the word addiction used in the context of antidepressants, mood stabilizers, etc..

Even non-psychiatric drugs like NSAIDs, insulin, hypertension medication, etc. can have a withdrawal effect.

I might be mistaken, but I am under the impression that addiction is psychological in nature. Take gambling addiction, for example, I am not certain if there is any physical withdrawal effect, but there is definitely a psychological compulsion.

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