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[return to "Adenosine on the common path of rapid antidepressant action: The coffee paradox"]
1. ifwint+dT[view] [source] 2025-12-06 07:51:30
>>PaulHo+(OP)
Maybe this is normal for mice but the dose of ketamine used (5-20 mg/kg) seems high? I know mice metabolism is very different but that's in the range of a gram of ketamine for a normal sized human.

The mice may not have been depressed because it's hard to be depressed when you're in a k hole

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2. cubefo+cZ[view] [source] 2025-12-06 09:14:39
>>ifwint+dT
I believe drug dosage scales with body surface rather than body mass, which scales differently.
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3. morkal+Pr1[view] [source] 2025-12-06 14:30:12
>>cubefo+cZ
Depends on the drug, no?
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4. cubefo+CD1[view] [source] 2025-12-06 16:06:33
>>morkal+Pr1
Not really. There a things like the square-cube law and Kleiber's law which indicate that drugs don't scale with weight. See

http://clymer.altervista.org/minor/allometry.html

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