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[return to "Adenosine on the common path of rapid antidepressant action: The coffee paradox"]
1. k1musa+Vi[view] [source] 2025-12-06 00:26:03
>>PaulHo+(OP)
On chronic coffee consumption: "One meta-analysis found that RR coffee 0.757, RR caffeine 0.721 (12). Another one found RR 0.76, with an optimal protective effect at ∼400 mL/day (13). In comparison to many drug treatments that have an effect size in this range, this is not a small effect size. A risk reduction of 20 to 25% is quite impressive."

As if I needed another reason to drink coffee.

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2. boothb+Wj[view] [source] 2025-12-06 00:33:25
>>k1musa+Vi
One thing I've learned over the years is that specifically setting out to enjoy and appreciate something on a daily basis is beneficial to overall satisfaction with life. And for me, that's my morning cuppa before the rest of the house wakes up. Is it (just) the coffee or is it (also) the rituals surrounding coffee?
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3. reacto+al[view] [source] 2025-12-06 00:44:08
>>boothb+Wj
It’s 100% the addiction.

It’s ok, me too. At home I’m a 4-6 cup a day drinker. On the go 2-3 Starbucks. I have a serious problem.

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4. superk+Jy[view] [source] 2025-12-06 03:02:52
>>reacto+al
Caffeine is not chemically addictive. It can lead to depedency but that is not addiction. Motivation and wanting are not altered but unpleasant withdrawl effects can occur.
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5. tayo42+FD[view] [source] 2025-12-06 03:51:54
>>superk+Jy
How do you explain the headaches and exhaustion durring withdrawal then?
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6. dist-e+CV[view] [source] 2025-12-06 08:26:50
>>tayo42+FD
Caffeine withdrawal takes 2 days.

The explanation for the headaches is that coffee raises blood pressure short term, and the blood vessels in the brain prepare for the predicted caffeine ingestion, and if it doesn't come there will be a mismatch.

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