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[return to "Adenosine on the common path of rapid antidepressant action: The coffee paradox"]
1. k1musa+Vi[view] [source] 2025-12-06 00:26:03
>>PaulHo+(OP)
On chronic coffee consumption: "One meta-analysis found that RR coffee 0.757, RR caffeine 0.721 (12). Another one found RR 0.76, with an optimal protective effect at ∼400 mL/day (13). In comparison to many drug treatments that have an effect size in this range, this is not a small effect size. A risk reduction of 20 to 25% is quite impressive."

As if I needed another reason to drink coffee.

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2. pinkmu+Vz[view] [source] 2025-12-06 03:14:41
>>k1musa+Vi
I don’t have hard data, but I think this optimal value is very closely approximated by coffee drinkers’ daily average. 400 ml is about 1.75 cups, and i think the normal distribution of coffee cups among drinkers is centered at ~2 cups. Makes me wonder if we’re all self medicating and accidentally finding the sweet spot.
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