Just in semi-recent history we had mccarthy 'cancelling' people for purportedly being linked to communism, and that was a whole lot more serious than some modern publisher refusing to buy your book or twitter banning you.
A few decades before that, it wasn't real uncommon that if your neighbors objected to who you were or what you said, for them to hang you by your neck from a convenient tree until you were quite dead.
Humans have always suffered penalties for being on the wrong side of their neighbor's majority opinions. These days the penalties are frankly pretty minor.
If I say the comment I'm replying to is stupid, have I just cancelled someone?
No, you would just be lying.