Congrats to Dalton and all involved. This is one of the most interesting and courageous internet projects in recent time.
Why does Hacker News exist? And other special interest web forums, Facebook groups, mailing lists? Who do interest groups hold meetups? People with shared interests get MASSIVE value from highly focused gatherings and conversations. And Twitter right now is anything but focused.
1) self moderation: Google Plus has circles which you can theoretically use to share specific topics only with circles that you know to be passionate about them. Requires manual work to setup the right circles and people rarely do it.
2) manual moderation: Hacker News uses pg's time and some admin/moderator supervision to trim unwanted topics. Requires manual work which expands proportionally with the community's size if no automation is used.
3) automatic moderation: HN's flag system and community moderation (voting, Slashdot karma) seem to work relatively well, but they've been used until now predominantly to "rank" good comments to the top as opposed to "clustering" online communities into "sub-reddits" with focused interest groups.