I did it with the Harfbuzz shaper which now have experimental support for embedding WebAssembly programs to shape fonts.
Talk where I show it off: https://www.youtube.com/watch?v=Ms1Drb9Vw9M
Source code: https://github.com/Erk-/programmable-fonts
You can also see actual uses of this WebAssembly embedding to show that is not just for fun here: https://github.com/harfbuzz/harfbuzz-wasm-examples
At the time it was also discussed on here at [1].
[0]: https://blog.erk.dev/posts/anifont/
[1]: >>37317055