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1. flobos+fd
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2023-08-03 09:56:37
>>atomro+(OP)
Not a medical chemist, but I noticed that three AOH1996 molecules are binding to PCNA. Would it make sense to chain together three AOH1996 molecules with flexible linkers for, I don't know, increased specificity or something like that?
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2. irdc+Yf
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2023-08-03 10:21:54
>>flobos+fd
Maybe. But a bigger molecule will be less soluble and less capable of getting into the cell.
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3. flobos+pm
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2023-08-03 11:18:35
>>irdc+Yf
Right! I forgot about good ol’ Lipinski:
https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five
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4. dekhn+t41
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2023-08-03 15:05:43
>>flobos+pm
it's more like guidelines than a rule.
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