Ironically, Jensen Huang did something like this many years ago. In an interview for his alma mater, he tells the story about how he had bet the existence of Nvidia on the successful usage of a new circuit simulation computer from a random startup that allowed Nvidia to complete the design of their chip.
Lumi: https://www.lumi-supercomputer.eu/lumis-full-system-architec...
If you know what your application would be and have the $300 million custom chips may be way more wise. Something you'd only get if you make things in-house/at startups.
Like... how you feel when you use them? (-: