The freedom problem is this: you will not be able to roll your own keys.
This is probably the biggest nail in the coffin for a ton of computers out there. In theory you could simulate via software the workings of a TPM. If you built a kernel module the browser would have no real way of knowing if it sent requests to a piece of hardware or a piece of software. But the fact that you would have to use Microsoft's or Apple's keys makes this completely impossible.
The hardware problem is this: you will not be able to use older or niche/independent hardware.
As we established that software simulation is impossible, this makes a ton of older devices utter e-waste for the near future. Most Chromebooks themselves don't have a TPM, so even though they are guaranteed updates for 10 years how are they going to browse the web? (maybe in that case Google could actually deploy a software TPM with their keys since it's closed source). I have a few old business laptops at home that have a 1.X version of the TPM. In theory it performs just as well as TPM 2.X, but they will not be supported because, again, I will not be able to use my own keys.
Lastly there is the social problem: is DRM the future of the web?
Maybe this trusted computing stuff really is what the web is bound to become, either using your certified TPM keys or maybe your Electronic National ID card or maybe both in order to attest the genuineness of the device that is making the requests. Maybe the Wild West era of the web was a silly dream fueled by novelty and inexperience and in the future we will look back and clearly see we needed more guarantees regarding web browsing, just like we need a central authority to guarantee and regulate SSL certificates or domain names.
We've allowed a lot of people to become really fucking lazy. That's the bottom line. Baby Boomers, some Millennials (not all), and a lot of Gen Z.
Generation X had no choice but to gain a strong knowledge of computers if they wanted to do anything on the Internet, because it was still difficult, it still required a little reading, and you couldn't just press the WPS button on your router to connect your new MacBook Pro.
Every single problem the web faces is that. Period.
A lot of people never had to learn jack shit, so they don't know jack shit. They can't tell the difference in a legitimate website versus one that isn't. They don't know how to read a web address. They can't figure out that irs.gov is legitimate and irs.4doad04ldud.com isn't. I have met people who are 50+ years old who have used Windows computers since they were 22 years old, but look absolutely goddamned dumbfounded when you tell them, "Just click on the Start button and go to Word."
Fuck.
Them.
Fuck every single one of them. We have tolerated lazy uninterested users for long enough. I'm not saying every computer user needs to be able to debug assembly code and fix their own driver issue by rewriting it from the ground up. I'm saying that as a society, we have progressed past the point where you can throw your hands up and say, "I'm JuSt NoT A CoMpUtEr PeRsOn!"
To quote Captain Jean-Luc Picard, "NOT GOOD ENOUGH! NOT GOOD ENOUGH, DAMMIT!"
And the entire industry across the entire planet and every single national, state, county, city, provencial, whatever government is going to have to get onboard, come together, and say, "Okay, here's a baseline set of knowledge about how computers and our communications systems work that every single human being needs to have."
You cannot "tech" your way out of this problem. Not without massive corporate and government overreach and invasion of people's privacy. Lazy shitty people are just going to have to be made to suffer until they stop being lazy and shitty. There are plenty of average IQ people who can grasp the basics of how their computer and the Internet work - but they're never made to. Well it's time to start making them.
The dumbing down of every single technological product and concept does our species no favors.