I've been staying with Firefox not for the performance (today Chrome loads Google sites like YouTube faster), but mainly for Tree Style Tab extension. I couldn't imagine opening more than a dozen of tabs without it.
I can't imagine having more than a dozen tabs open, period. You tab hoarders will never make sense to me...
For games, I often have a bunch of wiki tabs open at the same time.
I hardly use it, though, because I usually have < 100 open tabs, not thousands like others have. I identify tabs by their tree structures (parents, children, siblings tabs) and the prefixes of the titles, whose lengths don't depend on how many tabs opened, because the tabs are arranged vertically.