>>frugal+Oe
If your hypervisor supports nested virtualization, it should work. It'll probably grumble about the lack of IOMMU and various other things, but you should be able to run it in VMWare or KVM, if you're willing to jump through some hoops.
Not sure why you'd bother, though. If you're already spinning up VMs, just use that capability. Qubes makes "spinning up a ton of VMs on the iron" a lot easier and more usable.