It is more comfortable, but it's preferred using a wide DNS ad blocker as sites can only know that for some reason the DNS server can't resolve their domains. DNS ad blocker can also increase uniqueness.
Using an ad blocker extension can also cause security issues, as the extension has full control on network traffic and has potential to be exploited.
But loading ad's are the much greater security issue.
And if you care about "uniqueness" you have that already with your IP, so you should start there with yourOwnVPN, TOR etc.