>>amake+Qv1
Let blind people's text to speech readers read things. If you're printing it out, or you know it's for limited use digitally, go for it. But if you expect the public at large to read the digital text please make it text to speech accessible: no ligatures.
>>superk+rC1
The ligatures discussed are implemented at the rendering level. The byte sequence of text is unchanged vs the "no ligature" scenario. So this has zero impact on screen readers.