YMMV and it's certainly not for everyone. But I'm skeptical that staying in your comfort zone your whole life will do anyone much favors. (and the odd few week trip here or there doesn't really count, by all means all travel is great but vacation and just passing places through is fundamentally different from spending at least a few months or even years somewhere)
Isn’t that exactly what the comic is about?
I will say that I met my wife traveling and my kids were born on a different continent than me. There is a lot to find out there but travel as a value itself gets old and doesn’t fulfill your soul like it felt like it would when I was young.
Having a routine that makes you happy is important and not bad advice!
But sometimes, at least for me, I kind of exhaust my options for happiness in a given environment. Eg maybe I've already gotten a job with the best employer in a given location and can't climb any higher professionally, friends have moved away or started a family or whatever, hobbies and activities that used to be novel and fun have become repetitive and dull, I've mastered the local language I wanted to learn etc etc.
That feeling, combined with a basically infinite and always in flux list of places and things I want to experience before my time is up, makes switching my environment up very powerful and enjoyable for me.
Happily admit there's downsides to not "settling down" too and it's not for everyone. But I think most people would benefit from fundamentally switching up their environment at least a few times in their life. If it turns out you were happier where you started you can always go back. But you'll never know other places if you don't give them a shot.