This has nothing to do with the corona virus strains we are currently dealing with, and more importantly, there has never been any credible research proving that Covid was made in a lab. The only paper that got any traction suggested it was non-manipulation based gain of function research, but that was disproved only a few weeks after the paper's release as well. I know we all want to know where it came from, but the odds against us ever having actual evidence of it being from a lab are virtually zero. And no, rejected research proposals do not constitute proof of anything.
> Two, their proposal was for genetic manipulation of an existing virus, which research on the existing corona virus shows was not the case.
I think that’s invalidated if your first point is valid right? Since the proposal wasn’t accepted.
Doesn’t mean they didn’t go on to do it anyway (possibly in slightly different form), someone was clearly thinking about it.
No. There's evidence that COVID-19 was not created by direct genetic manipulation.
If they did it, it's not COVID-19.
There’s also evidence it cannot possibly (or well, with such a low chance it may as well be) have occured naturally.
What am I supposed to believe here? Even the people on my side of the fence, even the people that research this stuff themselves all seem to have an agenda and when research turns up one thing, I can practically guarantee that other research turns up the opposite.
There’s too much damn smoke in this whole thing for there to be no fire.
Now, I remember reading about it most likely not being a result of direct genetic manipulation, and it sounded sound to me.
Do you have any sources for your assertion that there is evidence it cannot have occurred naturally?
As far as I read such viruses have a natural tendency to sometimes jump species, as was likely the case with SARS-CoV and MERS.
People have asserted in this thread that it would take 30-40 years for the closest known natural covid relative to aquire the necessary 1000 mutations and turn into covid. And yet here we are, almost 2 years since the pandemic started, with no identified natural reservoir for covid.
Where is the covid source?
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Consider https://www.cell.com/cell/pdf/S0092-8674(21)00991-0.pdf, a pro natural origins review of the literature. They tie themselves into knots to explain that the infamous furin cleavage site, while absent in the closest covid relative, could have naturally occurred, even if they admit they have zero actual evidence for that.
> Although the furin cleavage site is absent from the closest known relatives of SARS-CoV-2 (Andersen et al., 2020), this is unsurprising because the lineage leading to this virus is poorly sampled and the closest bat viruses have divergent spike proteins due to recombination (Boni et al., 2020; Lytras et al., 2021; Zhou et al., 2021). Furin cleavage sites are commonplace in other coronavirus spike proteins, including some feline alphacoronaviruses, MERS-CoV, most but not all strains of mouse hepatitis virus, as well as in endemic human betacoronaviruses such as HCoV-OC43 and HCoV-HKU1 (Gombold et al., 1993; de Haan et al., 2008; Kirchdoerfer et al., 2016). A near identical nucleotide sequence is found in the spike gene of the bat coronavirus HKU9-1 (Gallaher, 2020), and both SARS-CoV-2 and HKU9-1 contain short palindromic sequences immediately upstream of this sequence that are indicative of natural recombination break-points via template switching (Gallaher, 2020). Hence, simple evolutionary mechanisms can readily explain the evolution of an out-of-frame insertion of a furin cleavage site in SARS-CoV-2 (Figure 2).
On the flip side, Nicholas Wade claims that Peter Daszak grant application proposes exactly that:
> The..grant proposal..now puts beyond doubt that engineering cleavage sites into SARS-like viruses was a technique to be explored at..Wuhan
https://nicholaswade.medium.com/new-routes-to-making-covid-1... (medium paywall, sorry) via https://twitter.com/R_H_Ebright/status/1441190122360225797.