The other problem is these OS's often don't seem to get very far. Seems like Qubes is launching beta 1. It's the kind of thing that one would expect needing a significant time to shake out.
Which isn't to say I wouldn't like to run a nicely implemented example of the concept. It certainly has the possibility of raising the bar significantly. Of course, it seems like no matter how far windows raises the bar people still keep on jumping it easily.