NameSilo, as far as I know, comes very close to the registry pricing and offers DNSSEC, nameserver registration and other APIs with the registry.
This could totally throw all registrars out of competition for the price of registry wholesale price. You just have to hope CloudFlare wouldn't overstep their role as a registrar if you only register the domain from them.
My only complaint with them is their DNS records are only updated once every 15 minutes.
This makes doing automated API based DNS based LE challenges annoying because you need to sleep your script for 15 minutes to ensure the update got pushed.
Also, I'm surprised Cloudflare omit talking about whois privacy in the blog post. Makes me wonder if they plan to sell that for some amount of money.
Cloudflare is also the largest authoritative DNS deployment in the world, and changes propagate in closer to 15 seconds than 15 minutes.