NixOS has containers that show how this could work, but they're only via systemd-nspawn, so not as jailed as Qube's domUs.
This means you can run Genode on NOVA with VirtualBox 5 fully integrated as the VMM, all with the improved Noux/POSIX interop components in place, and have a decent package management solution (that handles API compatibilities, multiple version installs, src vs binary deps, packages, and more). There's also Xen support with the most recent release (for cloud appliance work with Genode)
What's more, based on the roadmap and challenges, they should be bringing VirtualBox5 support to the seL4 kernel, and they even have a goal for being the virtualization foundation of QubesOS. https://genode.org/about/challenges
With the recent toolchain update and new package management system, its easier than ever to cook up your own Genode-based systems.