[1] https://blog.invisiblethings.org/
[2] https://blog.invisiblethings.org/papers/2015/state_harmful.p...
[3] https://blog.invisiblethings.org/papers/2015/x86_harmful.pdf
Seems like she'd have more effect designing hardware.
A: Stinkier without, therefore Qubes.
I'd consider betting on one of those things being solid on its own, but not all of them together.
If you've spent any time with Intel's phone-book-sized opcode manual, or following the history of the PC, you get real skeptical when the words "secure" and "PC" are mentioned together.