The closest you can get to Qubes on Windows would be to follow Microsoft's Privileged Access Workstation (PAW) guide, but it requires a lot of additional infrastructure[3]. That infrastructure allows you to do remote attestation of the virtual machines, but makes it costly to deploy in a SMB or homelab environment.
I don't expect it'll be very long before PAW and WDAG are usable at the same time, with colored window borders indicating the origin virtual machine. I hope this is on Microsoft's roadmap.
Video on privileged access workstation use, starting at a demo: https://youtu.be/3v8yQz2GWZw?t=41m48s
Video on privileged access workstation setup: https://www.youtube.com/watch?v=aPhfRTLXk_k
[1] https://docs.microsoft.com/en-us/windows/threat-protection/w...
[2] https://clearlinux.org/features/intel®-clear-containers
[3] https://docs.microsoft.com/en-us/windows-server/identity/sec...
Did you know if you force remove Edge from Windows 10 it will forever after ignore the "always use this" checkbox and prompt you to choose your default browser every time the browser is called from a link in an application?